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TitleSelective GLUT9 inhibitors for hyperuricemia via intestinal mechanism
Journal, issue, pagesActa Pharm Sin B, Year 2026
Publish dateJul 3, 2025 (structure data deposition date)
AuthorsZhao, Z. / Sun, Z. / Shen, Z. / Zheng, F. / Zhang, X. / Luo, Z. / He, Y. / Xu, Y. / Wu, Z. / Ke, J. ...Zhao, Z. / Sun, Z. / Shen, Z. / Zheng, F. / Zhang, X. / Luo, Z. / He, Y. / Xu, Y. / Wu, Z. / Ke, J. / Li, J. / Wu, T. / Zhang, Q. / Tian, Y. / Pan, X. / Pang, J. / Chen, J.
External linksActa Pharm Sin B / Search PubMed
MethodsEM (single particle)
Resolution3.14 Å
Structure data

PDB-9vpg:
Cryo-EM structure of human urate transporter GLUT9 bound to a selective inhibitor SG4
Method: ELECTRON MICROSCOPY / Resolution: 3.14 Å

Chemicals

PDB-1etz:
THE THREE-DIMENSIONAL STRUCTURE OF AN ANTI-SWEETENER FAB, NC10.14, SHOWS THE EXTENT OF STRUCTURAL DIVERSITY IN ANTIGEN RECOGNITION BY IMMUNOGLOBULINS

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / complex / selective inhibitor

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