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TitleDiscovery of Zipalertinib (TAS6417) as a Novel, Potent, Mutant Selective, and Orally Available Covalent EGFR Inhibitor Targeting EGFR Exon 20 Insertion Mutations in Non-Small Cell Lung Cancer
Journal, issue, pagesTo Be Published
Publish dateJul 2, 2025 (structure data deposition date)
AuthorsUno, T. / Suzuki, T.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.67 Å
Structure data

PDB-9voy:
EGFR T790M/L858R mutant in complex with covalent inhibitor TAS6417
Method: X-RAY DIFFRACTION / Resolution: 2.67 Å

Chemicals

ChemComp-X9H:
N-[(5P,8S,10R)-4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]prop-2-enamide

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / EGF RECEPTOR KINASE MUTANT T790M / L858R

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