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TitleA copper-dependent redox-based hydrogen peroxide perception in plants.
Journal, issue, pagesNat Commun, Vol. 17, Issue 1, Year 2026
Publish dateMay 18, 2026
AuthorsNobuaki Ishihama / Yohta Fukuda / Yumiko Shirano / Kazuhiro J Fujimoto / Kaori Takizawa / Ryoko Hiroyama / Hiroki Ito / Mayumi Nishimura / Takeshi Yanai / Tsuyoshi Inoue / Ken Shirasu / Anuphon Laohavisit /
PubMed AbstractRedox-related molecules, such as quinones and reactive oxygen species (ROS), are important signaling molecules for all living organisms. A plant-specific leucine-rich repeat receptor-like kinase (LRR- ...Redox-related molecules, such as quinones and reactive oxygen species (ROS), are important signaling molecules for all living organisms. A plant-specific leucine-rich repeat receptor-like kinase (LRR-RLK) CANNOT RESPOND TO DMBQ 1 (CARD1), also known as HYDROGEN-PEROXIDE-INDUCED Ca INCREASES (HPCA1), perceives both quinones and ROS, but the mechanism by which it distinguishes between these two types of signals remains unclear. Here, we determine the structure of the CARD1 ectodomain and uncover its unique features. Structural studies, coupled with genetics and biochemical analysis, demonstrate that previously identified unique cysteine residues are not essential for signal perception in CARD1. Interestingly, CARD1 harbors a copper ion on the surface of the ectodomain via histidine-coordination that is crucial for hydrogen peroxide signaling. Our work reports a unique copper-dependent redox perception in plants and provides insight into interactions between receptors and non-peptide stimuli during perception.
External linksNat Commun / PubMed:42151134 / PubMed Central
MethodsEM (single particle)
Resolution3.26 - 3.61 Å
Structure data

64920

9vbd

EMDB-64920, PDB-9vbd:
Cryo-EM structure of CARD1 ectodomain
Method: EM (single particle) / Resolution: 3.26 Å

64934

9vbv

EMDB-64934, PDB-9vbv:
Cryo-EM structure of a CARD1 ectodomain H197A/H199A/H222A mutant
Method: EM (single particle) / Resolution: 3.61 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CU:
COPPER (II) ION

Source
  • arabidopsis thaliana (thale cress)
  • escherichia coli k12 (bacteria)
KeywordsSIGNALING PROTEIN / leucine-rich repeat receptor-like kinase

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