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TitleDual Targeting of Topoisomerase I and DNA G-quadruplexes Enhances Senescence Response and Chemosensitivity in Colorectal Cancer Cells
Journal, issue, pagesTo Be Published
Publish dateJun 2, 2025 (structure data deposition date)
AuthorsLi, Y. / Ji, D. / Jia, Y. / Liang, Y. / Wei, E. / Gao, C. / Zeng, C. / Wang, L. / Wang, C. / Guo, Z. ...Li, Y. / Ji, D. / Jia, Y. / Liang, Y. / Wei, E. / Gao, C. / Zeng, C. / Wang, L. / Wang, C. / Guo, Z. / Zhang, Y. / Zhou, M.-M. / Wu, D. / Zeng, L.
External linksSearch PubMed
MethodsNMR (solution)
Structure data

PDB-9va0:
Solution NMR structures of hTERT DNA G-quadruplexes (G4s) in complex with small molecule CPT-11
Method: SOLUTION NMR

PDB-9va3:
Solution NMR structures of hTERT DNA G-quadruplexes (G4s) in complex with small molecule ZBH-01
Method: SOLUTION NMR

Chemicals

ChemComp-K:
Unknown entry

ChemComp-CP0:
(4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE / medication, anticancer*YM

PDB-1eq9:
CRYSTAL STRUCTURE OF FIRE ANT CHYMOTRYPSIN COMPLEXED TO PMSF

Source
  • homo sapiens (human)
KeywordsDNA / G-quadruplexes / Topoisomerase I / CPT-11 / Irinotecan / ZBH-01

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