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TitleStructural basis of a GatC ortholog transporter in the bacterial phosphotransferase system.
Journal, issue, pagesFEBS Lett, Vol. 599, Issue 16, Page 2377-2387, Year 2025
Publish dateAug 5, 2025
AuthorsYutaro S Takahashi / Hidetaka Kohga / Min Fey Chek / Kotomi Yamamoto / Jun F Takahashi / Hideki Shigematsu / Yoshiki Tanaka / Muneyoshi Ichikawa / Ryoji Miyazaki / Toshio Hakoshima / Tomoya Tsukazaki /
PubMed AbstractThe bacterial phosphotransferase system (PTS) mediates the uptake of specific carbohydrates via IIC transporters. Here, we report the crystal and cryo-electron microscopy (cryo-EM) structures of ...The bacterial phosphotransferase system (PTS) mediates the uptake of specific carbohydrates via IIC transporters. Here, we report the crystal and cryo-electron microscopy (cryo-EM) structures of Leminorella grimontii galactitol-specific PTS enzyme IIC component (LgGatC), which is implicated in D-xylose uptake and belongs to the ascorbate-galactitol (AG) superfamily of IIC proteins. These structures, determined in the presence and absence of D-xylose, capture the transporter in an outward-facing conformation. A homology model of an inward-facing state, constructed based on these structures, supports an elevator-like transport mechanism. These findings provide structural insights into substrate recognition by GatC and offer a framework for understanding sugar transport in PTS IIC proteins.
External linksFEBS Lett / PubMed:40878824
MethodsEM (single particle) / X-ray diffraction
Resolution2.7 - 3.74 Å
Structure data

63950

9u82

EMDB-63950, PDB-9u82:
Cryo-EM structure of Leminorella grimontii GatC in the presence of D-xylose
Method: EM (single particle) / Resolution: 2.7 Å

63951

9u84

EMDB-63951, PDB-9u84:
Cryo-EM structure of Leminorella grimontii GatC in the absence of D-xylose
Method: EM (single particle) / Resolution: 3.27 Å

PDB-9u8e:
Crystal structure of Leminorella grimontii GatC in the presence of D-xylose
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-9u8h:
Crystal structure of Leminorella grimontii GatC in the absence of D-xylose
Method: X-RAY DIFFRACTION / Resolution: 3.74 Å

Chemicals

ChemComp-OLC:
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate

Source
  • leminorella grimontii (bacteria)
KeywordsTRANSPORT PROTEIN / PTS / D-xylose / transporter / xylose

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