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Structure paper

TitlePenetrant PKC beta mutation in ATLL displays a mixed gain-of-function.
Journal, issue, pagesBiochem. J., Vol. 482, Page 1659-1675, Year 2025
Publish dateAug 6, 2025 (structure data deposition date)
AuthorsBrown, S.J. / Briggs, D.C. / Costello, P. / Yaguchi, H. / Bangham, C.R. / Parker, P.J. / McDonald, N.Q.
External linksBiochem. J. / PubMed:41091072
MethodsX-ray diffraction
Resolution3.425 Å
Structure data

PDB-9s9t:
Structure of human PKCBeta Kinase domain with Ruboxistaurin, D427N mutant
Method: X-RAY DIFFRACTION / Resolution: 3.425 Å

Chemicals

ChemComp-LY4:
(9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIA

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase / Inhibitor / Mutant

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