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TitleIntegrative structural analysis of the human endosomal Na/H exchanger NHE6 reveals lipid-modulated gating of the ion-binding site
Journal, issue, pagesTo Be Published
Publish dateJul 16, 2025 (structure data deposition date)
AuthorsFeilen LP / Sach L / Tranchant EE / Lalic MR / Havelund JF / Brauer CM / Ginsthofer M / Ostendorf J / Ma L / Morrow EM ...Feilen LP / Sach L / Tranchant EE / Lalic MR / Havelund JF / Brauer CM / Ginsthofer M / Ostendorf J / Ma L / Morrow EM / Faergeman NJ / Pedersen SF / Kragelund BB / Autzen HE
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.4 - 3.5 Å
Structure data

54418

9s0r

EMDB-54418, PDB-9s0r:
Cryo-EM structure of human NHE6 in C1 symmetry
Method: EM (single particle) / Resolution: 3.5 Å

54419

9s0s

EMDB-54419, PDB-9s0s:
Cryo-EM structure of human NHE6 in C2 symmetry
Method: EM (single particle) / Resolution: 3.4 Å

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / NHE / C1 symmetry / homodimer / transporter / C2 symmetry

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