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Structure paper

Title(-)-Englerin A binding to human TRPC5 exposes an aromatic interaction network in channel activation.
Journal, issue, pagesNat Commun, Year 2026
Publish dateJun 27, 2025 (structure data deposition date)
AuthorsPorav, S.A. / Ptakova, A. / Bauer, C.C. / Hammond, K.L.R. / Beech, D.J. / Vlachova, V. / Muench, S.P. / Bon, R.S.
External linksNat Commun / PubMed:42056091
MethodsEM (single particle)
Resolution2.3 - 3.2 Å
Structure data

PDB-9rrf:
TRPC5 apo cryoEM map in the presence of pluronic acid (PA), state 2
Method: ELECTRON MICROSCOPY / Resolution: 2.3 Å

PDB-9rrm:
Human TRPC5 in complex with (-) englerin A, full occupancy, state 1, on 290 nm gold foil holes (HexAuFoil)
Method: ELECTRON MICROSCOPY / Resolution: 2.5 Å

PDB-9rrn:
Human TRPC5 in complex with (-) englerin A, full occupancy, state 2, on 290 nm gold foil holes (HexAuFoil)
Method: ELECTRON MICROSCOPY / Resolution: 2.5 Å

PDB-9rro:
Human TRPC5 in complex with (-) englerin A, full occupancy, intermediary desensitized state
Method: ELECTRON MICROSCOPY / Resolution: 2.8 Å

PDB-9rrq:
Human TRPC5 in complex with (-) englerin A, partial occupancy (2EA:2LIP stoichiometry) state 1
Method: ELECTRON MICROSCOPY / Resolution: 2.9 Å

PDB-9rru:
Human TRPC5 in complex with (-) englerin A, mixed occupancy, state 1
Method: ELECTRON MICROSCOPY / Resolution: 3.2 Å

PDB-9rsg:
Human TRPC5 in complex with (-) englerin A, mixed occupancy_2, state 2
Method: ELECTRON MICROSCOPY / Resolution: 3.2 Å

PDB-9rsh:
Human TRPC5 in complex with (-) englerin A, mixed occupancy, state 2
Method: ELECTRON MICROSCOPY / Resolution: 3 Å

PDB-9rvv:
Human TRPC5 in complex with (-) englerin A, partial occupancy (2EA:2LIP stoichiometry) state 2
Method: ELECTRON MICROSCOPY / Resolution: 3 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-YZY:
(2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate

ChemComp-PTY:
PHOSPHATIDYLETHANOLAMINE / phospholipid*YM

ChemComp-Y01:
CHOLESTEROL HEMISUCCINATE

ChemComp-CA:
Unknown entry

PDB-1l55:
ANALYSIS OF THE INTERACTION BETWEEN CHARGED SIDE CHAINS AND THE ALPHA-HELIX DIPOLE USING DESIGNED THERMOSTABLE MUTANTS OF PHAGE T4 LYSOZYME

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Ion Channel / apo / TRPC5 / (-) englerin A / agonist

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