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Structure paper

TitleStructural and functional mapping of protective human monoclonal antibodies against enterovirus A71
Journal, issue, pagesScience Advances, Year 2026
Publish dateJun 11, 2025 (structure data deposition date)
AuthorsZhou D / Kotecha A / Kelly JT / Huang P / Chen Y / Walter TS / Duyvesteyn HME / Owens RJ / Ho S / Lin T ...Zhou D / Kotecha A / Kelly JT / Huang P / Chen Y / Walter TS / Duyvesteyn HME / Owens RJ / Ho S / Lin T / Fry EE / Ren J / Huang K / Stuart DI
External linksSearch PubMed
MethodsEM (single particle) / X-ray diffraction
Resolution1.14 - 4.8 Å
Structure data

53994

9rig

EMDB-53994, PDB-9rig:
EV-A71 (genotype B2) in complex with 16-2-9D Fab
Method: EM (single particle) / Resolution: 3.7 Å

53995

9rih

EMDB-53995, PDB-9rih:
EV-A71 (genotype B2) in complex with 16-2-12D Fab
Method: EM (single particle) / Resolution: 3.1 Å

53996

9rii

EMDB-53996, PDB-9rii:
EV-A71 (genotype B2) in complex with 34-1-6D Fab
Method: EM (single particle) / Resolution: 3.0 Å

53997

9rij

EMDB-53997, PDB-9rij:
EV-A71 (genotype B5) in complex with 16-2-8C Fab
Method: EM (single particle) / Resolution: 3.8 Å

53998

9rik

EMDB-53998, PDB-9rik:
EV-A71 (genotype B5) in complex with 16-2-2D Fab
Method: EM (single particle) / Resolution: 3.4 Å

53999

9ril

EMDB-53999, PDB-9ril:
EV-A71 (genotype B5) in complex with 16-3-3C Fab
Method: EM (single particle) / Resolution: 3.6 Å

54000

9rim

EMDB-54000, PDB-9rim:
EV-A71 (genotype B5) in complex with 16-3-4D Fab
Method: EM (single particle) / Resolution: 3.0 Å

54001

9rin

EMDB-54001, PDB-9rin:
EV-A71 (genotype B5) in complex with 17-1-12A Fab
Method: EM (single particle) / Resolution: 4.1 Å

54002

9rio

EMDB-54002, PDB-9rio:
EV-A71 (genotype B5) in complex with 17-2-2B Fab
Method: EM (single particle) / Resolution: 3.4 Å

54003

9rip

EMDB-54003, PDB-9rip:
EV-A71 (genotype B5) in complex with 17-2-12A Fab
Method: EM (single particle) / Resolution: 3.1 Å

54004

9riq

EMDB-54004, PDB-9riq:
EV-A71 (genotype C4) in complex with 16-2-11B Fab
Method: EM (single particle) / Resolution: 3.3 Å

54005

9rir

EMDB-54005, PDB-9rir:
EV-A71 (genotype C4) in complex with 16-3-10B Fab
Method: EM (single particle) / Resolution: 3.3 Å

55620

9t6z

EMDB-55620, PDB-9t6z:
EV-A71 (genotype B5) empty particle in complex with 16-3-3C Fab
Method: EM (single particle) / Resolution: 4.8 Å

PDB-9i3w:
Structure of anti-EV71 human monoclonal antibody 16-2-8C Fab
Method: X-RAY DIFFRACTION / Resolution: 1.14 Å

PDB-9i3z:
Structure of anti-EV71 human monoclonal antibody 16-2-12D Fab
Method: X-RAY DIFFRACTION / Resolution: 3.06 Å

PDB-9i40:
Structure of anti-EV71 human monoclonal antibody 16-3-4D Fab
Method: X-RAY DIFFRACTION / Resolution: 2.78 Å

PDB-9i41:
Structure of anti-EV71 human monoclonal antibody 16-3-3C Fab
Method: X-RAY DIFFRACTION / Resolution: 1.32 Å

PDB-9i42:
Structure of anti-EV71 human monoclonal antibody 16-2-2D Fab
Method: X-RAY DIFFRACTION / Resolution: 1.92 Å

PDB-9i43:
Structure of anti-EV71 human monoclonal antibody 16-2-9D Fab
Method: X-RAY DIFFRACTION / Resolution: 1.18 Å

PDB-9i45:
Structure of anti-EV71 human monoclonal antibody 16-3-10B Fab
Method: X-RAY DIFFRACTION / Resolution: 2.12 Å

PDB-9i4b:
Structure of anti-EV71 human monoclonal antibody 17-2-12A Fab
Method: X-RAY DIFFRACTION / Resolution: 2.68 Å

PDB-9i4c:
Structure of anti-EV71 human monoclonal antibody 17-1-12A Fab
Method: X-RAY DIFFRACTION / Resolution: 2.83 Å

PDB-9i4d:
Structure of anti-EV71 human monoclonal antibody 17-2-2B Fab
Method: X-RAY DIFFRACTION / Resolution: 2.56 Å

PDB-9i4e:
Structure of anti-EV71 human monoclonal antibody 34-1-6D Fab
Method: X-RAY DIFFRACTION / Resolution: 1.63 Å

Chemicals

ChemComp-BTB:
2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-ACT:
ACETATE ION

ChemComp-SPH:
SPHINGOSINE

Source
  • Enterovirus A71
  • homo sapiens (human)
  • chlorocebus aethiops (grivet monkey)
  • human enterovirus 71
KeywordsANTIVIRAL PROTEIN / EV71 / antibody / 16-2-8C / Fab / 16-2-12D / 16-3-4D / 16-3-3C / 16-2-2D / 16-2-9D / 16-3-10B / 17-2-12A / 17-1-12A / 17-2-2B / 34-1-6D / VIRUS / Hand-foot-and-mouth disease / HFMD / enterovirus 71 (EV-A71) / Human antibody / 17-1-2B / 16-2-11B

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