+検索条件
-Structure paper
| タイトル | Cryo-EM Observation of AA Amyloid Fibrils in Mouse Model of Systemic AApoAII Amyloidosis. |
|---|---|
| ジャーナル・号・ページ | J Mol Biol, Vol. 437, Issue 24, Page 169438, Year 2025 |
| 掲載日 | 2025年9月11日 |
著者 | Giada Andreotti / Keichii Higuchi / Matthias Schmidt / Marcus Fändrich / ![]() |
| PubMed 要旨 | The co-deposition of amyloid fibrils from different precursor proteins is a topic of increasing relevance for protein misfolding diseases. Using cryo-electron microscopy (cryo-EM), we here determined ...The co-deposition of amyloid fibrils from different precursor proteins is a topic of increasing relevance for protein misfolding diseases. Using cryo-electron microscopy (cryo-EM), we here determined the structures of two serum amyloid A (SAA) protein-derived amyloid fibril morphologies that were extracted from a mouse strain that is primarily known to be associated with apolipoprotein A-II-derived amyloid fibrils. The two fibril morphologies show the same protomer conformation as in previously reported ex vivo amyloid fibrils from SAA protein but a different relative arrangement of fibril protein stacks. These data establish that serum amyloid A-derived amyloid fibrils share the same fibril protein fold in different mouse strains and disease contexts. |
リンク | J Mol Biol / PubMed:40945578 |
| 手法 | EM (らせん対称) |
| 解像度 | 3.5 Å |
| 構造データ | EMDB-53573, PDB-9r4z: |
| 由来 |
|
キーワード | PROTEIN FIBRIL / Amyloid fibril / AA amyloidosis / systemic amyloidosis / AApoAII amyloidosis / misfolfing disease / protein aggregation |
ムービー
コントローラー
構造ビューア
万見文献について



著者

リンク


キーワード