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TitleHuman neutralizing antibodies targeting the measles virus hemagglutinin and fusion surface proteins.
Journal, issue, pagesCell Host Microbe, Vol. 34, Page 1067-1081.e12, Year 2026
Publish dateAug 14, 2025 (structure data deposition date)
AuthorsMarissa Acciani / Dawid Zyla / Gele Niemeyer / Stephanie Harkins / Diptiben Parekh / Emily Pawlack / Davide Lacarbonara / Dhvanir Kansara / Margaret E Ackerman / Stefan Niewiesk / Matteo Porotto / Kathryn M Hastie / Erica Ollmann Saphire /
PubMed AbstractMeasles virus (MeV), a highly transmissible paramyxovirus, can cause severe complications and death, particularly in infants and young children. How and where human antibodies target and neutralize ...Measles virus (MeV), a highly transmissible paramyxovirus, can cause severe complications and death, particularly in infants and young children. How and where human antibodies target and neutralize MeV remain unclear. Here, we report a panel of human monoclonal antibodies (mAbs) specific for MeV hemagglutinin (H) and fusion (F) surface proteins, derived from the memory B cells of a Measles-Mumps-Rubella (MMR) vaccinee. We mapped four and five major epitope clusters on H and F, respectively, and structurally characterized representative mAbs from each epitope cluster. MAbs against both H and F offer broad, potent, picomolar-level neutralization and substantially reduce viral loads in vivo when delivered before or after viral exposure. High-resolution cryo-electron microscopy of mAb complexes with H and F reveal highly conserved contact sites of the most protective antibodies. Characterization of these fully human mAbs provides avenues for prophylactic or therapeutic intervention against re-emerging MeV.
External linksCell Host Microbe / PubMed:42102820
MethodsEM (single particle)
Resolution2.3 - 3.25 Å
Structure data

PDB-9q1z:
Structure of the Measles virus Hemagglutinin ectodomain in complex with neutralizing antibody 1C02
Method: ELECTRON MICROSCOPY / Resolution: 3.05 Å

PDB-9q20:
Structure of the Measles virus Hemagglutinin ectodomain in complex with neutralizing antibody 1C08
Method: ELECTRON MICROSCOPY / Resolution: 3.25 Å

PDB-9q24:
Structure of the Measles virus Hemagglutinin ectodomain in complex with two neutralizing antibodies 1C08 and 4D08
Method: ELECTRON MICROSCOPY / Resolution: 3.25 Å

PDB-9q26:
Structure of the Measles virus Fusion glycoprotein ectodomain in complex with two neutralizing antibodies 4F09 and 3A12
Method: ELECTRON MICROSCOPY / Resolution: 2.3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-MAN:
alpha-D-mannopyranose

Source
  • homo sapiens (human)
  • measles morbillivirus
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / VIRAL PROTEIN / glycoprotein / immune system / measles / high-resolution / ectodomain / attachment / antibody / complex / VIRAL PROTEIN-IMMUNE SYSTEM complex / fusion

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