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TitleHigh-affinity, structure-validated and selective macrocyclic peptide tools for chemical biology studies of Huntingtin.
Journal, issue, pagesProc Natl Acad Sci U S A, Vol. 123, Issue 12, Page e2520462123, Year 2026
Publish dateMar 24, 2026
AuthorsRebeka Fanti / Esther Wolf / Tatsuya Ikenoue / Justin C Deme / Swati Balakrishnan / Brandon A Keith / Matthew G Alteen / Renu Chandrasekaran / Manisha Yadav / Ritika Bhajiawala / Suzanne Ackloo / Jia Feng / Mahmoud A Pouladi / Aled M Edwards / Derek J Wilson / Susan M Lea / Hiroaki Suga / Rachel J Harding /
PubMed AbstractHuntington's disease (HD) is a fatal neurodegenerative disorder caused by a Cytosine-Adenosine-Guanine (CAG) repeat expansion in the () gene, with no disease-modifying therapies currently available. ...Huntington's disease (HD) is a fatal neurodegenerative disorder caused by a Cytosine-Adenosine-Guanine (CAG) repeat expansion in the () gene, with no disease-modifying therapies currently available. The precise molecular function of the HTT protein is unclear, and the lack of selective chemical tools has limited functional studies. We have identified and characterized macrocyclic peptide binders targeting HTT. These binders exhibit low-nanomolar affinity in vitro and engage distinct HTT and HTT-HAP40 interfaces, as revealed by hydrogen-deuterium exchange mass spectrometry and cryoelectron microscopy. Chemoproteomics confirmed selective binding in cell extracts from wildtype but not HTT-null cell lines. HAP40 consistently and stoichiometrically copurified with HTT across cell lines, including with HTT variants containing different CAG repeat lengths, highlighting the broad presence of the HTT-HAP40 complex.
External linksProc Natl Acad Sci U S A / PubMed:41838909 / PubMed Central
MethodsEM (single particle)
Resolution2.1 - 2.3 Å
Structure data

71743

9pmw

EMDB-71743, PDB-9pmw:
Structure of HTTQ23-HAP40 complex bound to macrocycles HHL1, HD4 and HL2
Method: EM (single particle) / Resolution: 2.1 Å

71744

9pn0

EMDB-71744, PDB-9pn0:
Structure of HTTQ23-HAP40 complex bound to macrocycles HHD3, HD4 and HL2
Method: EM (single particle) / Resolution: 2.3 Å

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsPEPTIDE BINDING PROTEIN / Huntingtin / Macrocycles / Polyglutamine expansion

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