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TitleMolecular architecture of the fungal-specific potassium channel TOK1.
Journal, issue, pagesNat Commun, Year 2026
Publish dateApr 27, 2026
AuthorsBrice Durocher / Rían W Manville / Rui Yan / Zhiheng Yu / Geoffrey W Abbott / Alexandria N Miller /
PubMed AbstractIn Candida albicans, potassium (K) channels fine-tune ionic balance under stress, contributing to host colonization. Fungal two-pore domain, outwardly rectifying potassium (TOK) channels remain ...In Candida albicans, potassium (K) channels fine-tune ionic balance under stress, contributing to host colonization. Fungal two-pore domain, outwardly rectifying potassium (TOK) channels remain insufficiently characterized despite evidence implicating them in growth and viability. Here, we describe the atomic-resolution structure of a fungal potassium channel, TOK1 from C. albicans (CaTOK), revealing an architecture defined by eight transmembrane helices and a membrane topology distinct from previously characterized K⁺ channel classes. The first four helices form a tetraspanin-like bundle resembling auxiliary subunits of human neuronal ion channels. The pore features an inner helical gating movement analogous to mammalian dimeric K channels, while the K selectivity filter exhibits atypical ion coordination. A cytosolic C-terminal bundle forms an intramolecular network that likely stabilizes CaTOK and may mediate gating. These findings provide a framework for understanding TOK channel function and facilitate future studies of fungal ion homeostasis, pathogenicity, and therapeutic development.
External linksNat Commun / PubMed:42045187
MethodsEM (single particle)
Resolution2.62 - 3.05 Å
Structure data

71670

9pik

EMDB-71670, PDB-9pik:
Structure of the two-pore domain, outwardly rectifying potassium (TOK1) from Candida albicans, overall structure
Method: EM (single particle) / Resolution: 2.62 Å

71702

9pko

EMDB-71702, PDB-9pko:
Structure of the two-pore domain, outwardly rectifying potassium (TOK1) from Candida albicans, Up conformation
Method: EM (single particle) / Resolution: 2.8 Å

71703

9pkp

EMDB-71703, PDB-9pkp:
Structure of the two-pore domain, outwardly rectifying potassium (TOK1) from Candida albicans, Down conformation
Method: EM (single particle) / Resolution: 3.05 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-LMT:
DODECYL-BETA-D-MALTOSIDE / detergent*YM

Source
  • candida albicans (yeast)
KeywordsMETAL TRANSPORT / potassium ion channel

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