+Search query
-Structure paper
| Title | Cryo-EM-guided subtractive optimization of a novel VCP/p97 inhibitor |
|---|---|
| Journal, issue, pages | To Be Published |
| Publish date | May 5, 2025 (structure data deposition date) |
Authors | Crawford J / Munuganti R / Leung C / Singh K / Gates E / Zhu X / Bally M / Dos Santos N / Sharifiaghdam M / Nosrati Z ...Crawford J / Munuganti R / Leung C / Singh K / Gates E / Zhu X / Bally M / Dos Santos N / Sharifiaghdam M / Nosrati Z / Axerio-Cilies P / Berezuk A / Cholak S / Cameron D / Subramaniam S |
External links | Search PubMed |
| Methods | EM (single particle) |
| Resolution | 2.46 - 2.72 Å |
| Structure data | EMDB-70500, PDB-9ohm: EMDB-70501, PDB-9ohn: |
| Chemicals | ![]() ChemComp-PCG: ![]() ChemComp-ZN: ![]() ChemComp-MG: ![]() ChemComp-JDP: ![]() ChemComp-ADP: ![]() PDB-1cbf: |
| Source |
|
Keywords | SIGNALING PROTEIN / GAF domain / phosphohydrolase / G protein-coupled receptor signaling / CB-5083 / HYDROLASE/HYDROLASE INHIBITOR / p97 / VCP / TERA / Inhibitor / GND-135 / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complex |
Movie
Controller
Structure viewers
About Yorodumi Papers



Authors
External links










homo sapiens (human)
Keywords