| Title | Development of a tau amyloid dye from a PET ligand |
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| Journal, issue, pages | To Be Published |
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| Publish date | Apr 14, 2025 (structure data deposition date) |
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Authors | Kunach P / Diamond MI |
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External links | Search PubMed |
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| Methods | EM (helical sym.) |
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| Resolution | 2.31 - 2.72 Å |
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| Structure data | EMDB-70182, PDB-9o6v: Recombinant AD PHF complexed with SW-MK-NBD (PHF2) Method: EM (helical sym.) / Resolution: 2.72 Å EMDB-70183, PDB-9o6w: Recombinant AD PHF complexed with SW-MK-NBD (Non Symmetric Binding Site) Method: EM (helical sym.) / Resolution: 2.67 Å EMDB-70184, PDB-9o6x: Recombinant AD THF incubated with SW-MK-NBD (Non-Symmetric Binding) Method: EM (helical sym.) / Resolution: 2.58 Å EMDB-70185, PDB-9o6y: Recombinant AD PHF complexed with SW-MK-NBD Method: EM (helical sym.) / Resolution: 2.72 Å EMDB-70187, PDB-9o6z: Recombinant AD THF with SW-MK-NBD complexed in AD-related Binding Site Method: EM (helical sym.) / Resolution: 2.31 Å EMDB-70188, PDB-9o76: Recombinant AD THF complexed with SW-MK-NBD (Secondary Binding Site) Method: EM (helical sym.) / Resolution: 2.58 Å EMDB-70191, PDB-9o79: Recombinant AD PHF incubated with DMSO (Kinked Backbone E342) Method: EM (helical sym.) / Resolution: 2.55 Å EMDB-70193, PDB-9o7b: Recombinant AD THF incubated with DMSO (Kinked Backbone E342) Method: EM (helical sym.) / Resolution: 2.31 Å EMDB-70194, PDB-9o7c: Recombinant AD THF incubated with DMSO (Flat Backbone E342) Method: EM (helical sym.) / Resolution: 2.31 Å |
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| Chemicals | |
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| Source | homo sapiens (human)
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Keywords | PROTEIN FIBRIL / MK-6240 PET Ligand / AD PHF / SW-MK-NBD / Amyloid Dye |
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