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TitleAcyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.
Journal, issue, pagesNucleic Acids Res., Vol. 54, Year 2026
Publish dateApr 8, 2025 (structure data deposition date)
AuthorsChickering, T. / Harp, J.M. / Jiang, Y. / Qin, J. / He, G. / Hyde, S. / Ihlefeld, A. / Janas, M. / O'Flaherty, D.K. / Schofield, S. ...Chickering, T. / Harp, J.M. / Jiang, Y. / Qin, J. / He, G. / Hyde, S. / Ihlefeld, A. / Janas, M. / O'Flaherty, D.K. / Schofield, S. / Szeto, J. / Theile, C.S. / Charisse, K. / Jadhav, V. / Maier, M.A. / Manoharan, M. / Egli, M. / Schlegel, M.K.
External linksNucleic Acids Res. / PubMed:41994868
MethodsX-ray diffraction
Resolution1.6 Å
Structure data

PDB-9o47:
RNA dodecamer containing a serinol nucleic acid.
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

PDB-1b9t:
NOVEL AROMATIC INHIBITORS OF INFLUENZA VIRUS NEURAMINIDASE MAKE SELECTIVE INTERACTIONS WITH CONSERVED RESIDUES AND WATER MOLECULES IN THE ACTIVE SITE

ChemComp-5BU:
5-BROMO-URIDINE-5'-MONOPHOSPHATE

ChemComp-5GP:
GUANOSINE-5'-MONOPHOSPHATE

ChemComp-C5P:
CYTIDINE-5'-MONOPHOSPHATE

ChemComp-C:
CYTIDINE-5'-MONOPHOSPHATE

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
KeywordsRNA / serinol nucleic acid

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