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TitleB7-H3-mediated cis-inhibition of EGFR by a tumor-selective bispecific antibody enhances anti-tumor efficacy and minimizes on-target toxicities
Journal, issue, pagesTo Be Published
Publish dateFeb 19, 2025 (structure data deposition date)
AuthorsBin L / Shuaixiang Z / Kaijie H
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.98 - 3.67 Å
Structure data

63503

9ly5

EMDB-63503, PDB-9ly5:
antibody 20G5 Fab in complex with human B7-H3 (IgC)
Method: EM (single particle) / Resolution: 2.98 Å

63505

9ly6

EMDB-63505, PDB-9ly6:
antibody 20G5 (Fab')2 in complex with human B7-H3
Method: EM (single particle) / Resolution: 3.67 Å

Source
  • homo sapiens (human)
KeywordsANTITUMOR PROTEIN/IMMUNE SYSTEM / B7-H3 / antibody / complex / ANTITUMOR PROTEIN-IMMUNE SYSTEM complex

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