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Structure paper

TitleMicroscopic and structural observations of actin filament capping and severing by cytochalasin D.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 122, Page e2502164122-e2502164122, Year 2025
Publish dateDec 17, 2024 (structure data deposition date)
AuthorsMitani, T. / Takeda, S. / Oda, T. / Narita, A. / Maeda, Y. / Honda, H. / Fujiwara, I.
External linksProc. Natl. Acad. Sci. USA / PubMed:40658853
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-9l2n:
Crystal structure of Cytochalasin D bound to a filamentous conformation actin
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-PO4:
PHOSPHATE ION

ChemComp-MG:
Unknown entry

ChemComp-CY9:
(3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylidene-1,11-dioxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate / inhibitor, alkaloid, toxin*YM

ChemComp-CA:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • physarum polycephalum (eukaryote)
  • gallus gallus (chicken)
KeywordsCYTOSOLIC PROTEIN / Actin dynamics / Cytochalasin / Actin drugs

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