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Structure paper

TitleStructural basis for recognition of two different drugs by human OAT1
Journal, issue, pagesTo be published
Publish dateAug 2, 2024 (structure data deposition date)
AuthorsWu XN / Luo YB / Feng SJ
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.15 - 3.68 Å
Structure data

61046

9j02

EMDB-61046, PDB-9j02:
cryo-EM structure of apo hOAT1
Method: EM (single particle) / Resolution: 3.36 Å

61048

9j04

EMDB-61048, PDB-9j04:
Cryo-EM structure of hOAT1 in complex with cidofovir
Method: EM (single particle) / Resolution: 3.15 Å

61050

9j06

EMDB-61050, PDB-9j06:
Cryo-EM structure of hOAT1 in complex with glibenclamide
Method: EM (single particle) / Resolution: 3.68 Å

Chemicals

ChemComp-L8P:
({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid / medication, antivirus*YM

ChemComp-GBM:
5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide / medication*YM

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / transporter / Organic Anion / uptake / renal pathophysiology

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