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Structure paper

TitleSertraline and Astemizole Enhance the Deubiquitinase Activity of USP7 by Binding to Its Switching Loop Region.
Journal, issue, pagesJ. Med. Chem., Vol. 68, Page 5874-5890, Year 2025
Publish dateJun 25, 2024 (structure data deposition date)
AuthorsShi, L. / Xu, Z. / Chen, X. / Meng, Q. / Zhou, H. / Xiong, B. / Zhang, N.
External linksJ. Med. Chem. / PubMed:39999290
MethodsX-ray diffraction
Resolution2.46 - 2.78 Å
Structure data

PDB-9iju:
Sertraline enhances the deubiquitinase activity of USP7 by binding to its switching loop region
Method: X-RAY DIFFRACTION / Resolution: 2.46 Å

PDB-9iml:
Sertraline enhances the deubiquitinase activity of USP7 by binding to its switching loop region
Method: X-RAY DIFFRACTION / Resolution: 2.78 Å

Chemicals

ChemComp-SRE:
(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine / medication, antidepressant, inhibitor*YM

ChemComp-HOH:
WATER

ChemComp-XB7:
1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine

Source
  • homo sapiens (human)
KeywordsHYDROLASE / ubiquitin specific protease

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