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Structure paper

TitleA Coiled Coil Module Strategy for High-Resolution Cryo-EM Structures of Small Proteins for Drug Discovery
Journal, issue, pagesTo Be Published
Publish dateJan 28, 2025 (structure data deposition date)
AuthorsSamson C / Dossou I / Steinmetz A / Kumar A / Mathieu M / Rak A
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.77 Å
Structure data

52628

9i5e

EMDB-52628, PDB-9i5e:
A Coiled Coil Module Strategy for High-Resolution Cryo-EM Structures of Small Proteins for Drug Discovery
Method: EM (single particle) / Resolution: 3.77 Å

Chemicals

ChemComp-M1X:
{(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-1-[(2S)-2-fluoropropanoyl]piperazin-2-yl}acetonitrile

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsSTRUCTURAL PROTEIN / cryoem imaging scaffold / cancer / gtpase / nanobodies / coiled-coil

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