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TitleIdentification, validation, and characterization of approved and investigational drugs interfering with the SARS-CoV-2 endoribonuclease Nsp15.
Journal, issue, pagesProtein Sci., Vol. 34, Page e70156-e70156, Year 2025
Publish dateNov 21, 2024 (structure data deposition date)
AuthorsChatziefthymiou, S.D. / Kuzikov, M. / Afandi, S. / Kovacs, G. / Srivastava, S. / Zaliani, A. / Gruzinov, A. / Pompidor, G. / Lunelli, M. / Ahmed, G.R. ...Chatziefthymiou, S.D. / Kuzikov, M. / Afandi, S. / Kovacs, G. / Srivastava, S. / Zaliani, A. / Gruzinov, A. / Pompidor, G. / Lunelli, M. / Ahmed, G.R. / Labahn, J. / Hakanpaa, J. / Windshugel, B. / Kolbe, M.
External linksProtein Sci. / PubMed:40371758
MethodsX-ray diffraction / small angle scattering
Resolution2 - 2.08 Å
Structure data

PDB-9hh5:
Crystal Structure of nsp15 Endoribonuclease from SARS CoV-2 in Complex with Sepantronium (YM-155)
Method: X-RAY DIFFRACTION / Resolution: 2.08 Å

PDB-9hh6:
Crystal Structure of Nsp15 Endoribonuclease from SARS CoV-2 in Complex with TAS-103
Method: X-RAY DIFFRACTION / SOLUTION SCATTERING / Resolution: 2 Å

Chemicals

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-GXU:
1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione

ChemComp-HOH:
WATER

PDB-1iuv:
P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-4-HYDROXYBENZOATE AT PH 5.0

ChemComp-PO4:
PHOSPHATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN / Uridylate-specific endoribonuclease

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