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TitleAsgard archaea reveal the conserved principles of ESCRT-III membrane remodeling.
Journal, issue, pagesSci Adv, Vol. 11, Issue 6, Page eads5255, Year 2025
Publish dateFeb 7, 2025
AuthorsDiorge P Souza / Javier Espadas / Sami Chaaban / Edmund R R Moody / Tomoyuki Hatano / Mohan Balasubramanian / Tom A Williams / Aurélien Roux / Buzz Baum /
PubMed AbstractESCRT-III proteins assemble into composite polymers that undergo stepwise changes in composition and structure to deform membranes across the tree of life. Here, using a phylogenetic analysis, we ...ESCRT-III proteins assemble into composite polymers that undergo stepwise changes in composition and structure to deform membranes across the tree of life. Here, using a phylogenetic analysis, we demonstrate that the two endosomal sorting complex required for transport III (ESCRT-III) proteins present in eukaryote's closest Asgard archaeal relatives are evolutionarily related to the B- and A-type eukaryotic paralogs that initiate and execute membrane remodeling, respectively. We show that Asgard ESCRT-IIIB assembles into parallel arrays on planar membranes to initiate membrane deformation, from where it recruits ESCRT-IIIA to generate composite polymers. Last, we show that Asgard ESCRT-IIIA is able to remodel membranes into tubes as a likely prelude to scission. Together, these data reveal a set of conserved principles governing ESCRT-III-dependent membrane remodeling that first emerged in a two-component ESCRT-III system in archaea.
External linksSci Adv / PubMed:39919172 / PubMed Central
MethodsEM (helical sym.)
Resolution2.91 - 6.5 Å
Structure data

50748

9ftl

EMDB-50748, PDB-9ftl:
Asgard ESCRT-IIIB filament structure
Method: EM (helical sym.) / Resolution: 2.91 Å

50749

9ftm

EMDB-50749, PDB-9ftm:
Asgard ESCRT-IIIB membrane-bound protofilament structure
Method: EM (helical sym.) / Resolution: 6.5 Å

Source
  • candidatus heimdallarchaeota archaeon (archaea)
KeywordsMEMBRANE PROTEIN / ESCRT-III / filament / membrane binding protein / membrane remodelling / Asgard archaea / membrane remodeling

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