+Search query
-Structure paper
Title | Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia. |
---|---|
Journal, issue, pages | Mol. Ther., Year 2025 |
Publish date | Mar 25, 2024 (structure data deposition date) |
![]() | Ahmed, S.F. / Anand, J. / Zhang, W. / Buetow, L. / Rishi, L. / Mitchell, L. / Bohlen, J. / Lilla, S. / Sibbet, G.J. / Nixon, C. ...Ahmed, S.F. / Anand, J. / Zhang, W. / Buetow, L. / Rishi, L. / Mitchell, L. / Bohlen, J. / Lilla, S. / Sibbet, G.J. / Nixon, C. / Patel, A. / Majorek, K.A. / Zanivan, S. / Bustamante, J.C. / Sidhu, S.S. / Blyth, K. / Huang, D.T. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.02 Å |
Structure data | ![]() PDB-9erz: |
Chemicals | ![]() ChemComp-CA: ![]() ChemComp-HOH: |
Source |
|
![]() | LIGASE / Ubiquitin ligase / CBL / peptide inhibitor |