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TitleThe Phosphatase RosC from Streptomyces davaonensis is Used for Roseoflavin Biosynthesis and has Evolved to Largely Prevent Dephosphorylation of the Important Cofactor Riboflavin-5'-phosphate.
Journal, issue, pagesJ. Mol. Biol., Vol. 436, Page 168734-168734, Year 2024
Publish dateFeb 28, 2024 (structure data deposition date)
AuthorsJoshi, T. / Demmer, U. / Schneider, C. / Glaser, T. / Warkentin, E. / Ermler, U. / Mack, M.
External linksJ. Mol. Biol. / PubMed:39097184
MethodsX-ray diffraction
Resolution1.25 - 1.7 Å
Structure data

PDB-8s6q:
RosC
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-8s6r:
RosC-8.demethyl-8-amino-riboflavin complex
Method: X-RAY DIFFRACTION / Resolution: 1.25 Å

PDB-9emu:
RosC-8-demethyl-8-amino-FMN - Phosphate complex
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-IOD:
IODIDE ION

ChemComp-NA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-RS3:
1-deoxy-1-[8-(dimethylamino)-7-methyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl]-D-ribitol

ChemComp-PO4:
PHOSPHATE ION

Source
  • streptomyces davaonensis (bacteria)
KeywordsHYDROLASE / Streptomyces davaonensis / roseoflavin / riboflavin / phosphatases / antibiotics / RosC / phosphatase

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