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TitleBlocking activation of the C1r zymogen defines a novel mode of complement inhibition.
Journal, issue, pagesJ. Biol. Chem., Vol. 301, Page 108301-108301, Year 2025
Publish dateDec 2, 2024 (structure data deposition date)
AuthorsDuan, H. / Wu, W. / Li, P. / Bouyain, S. / Garcia, B.L. / Geisbrecht, B.V.
External linksJ. Biol. Chem. / PubMed:39947467
MethodsX-ray diffraction
Resolution3.1 - 3.28 Å
Structure data

PDB-9ekd:
Structure of a C1r Zymogen Fragment Bound to SALO
Method: X-RAY DIFFRACTION / Resolution: 3.28 Å

PDB-9eke:
Structure of a C1r Zymogen Fragment Bound to SALO, Y51F Mutant
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Source
  • lutzomyia longipalpis (insect)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / HYDROLASE / complement system / C1r / zymogen / inhibitor

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