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TitleCryo-EM structure of inactive and active prostaglandin D2 receptor
Journal, issue, pagesTo Be Published
Publish dateFeb 27, 2024 (structure data deposition date)
AuthorsDavoudinasab B / Han GW / Cherezov V
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.45 - 2.68 Å
Structure data

43839

9au0

EMDB-43839, PDB-9au0:
Cryo-EM structure of the BW245C-bound prostaglandin D2 receptor (DP1)-Gs complex
Method: EM (single particle) / Resolution: 2.45 Å

47802

9e9s

EMDB-47802, PDB-9e9s:
Cryo-EM structure of the PGD2-bound prostaglandin D2 receptor (DP1)-Gs complex
Method: EM (single particle) / Resolution: 2.68 Å

Chemicals

PDB-1af8:
ACTINORHODIN POLYKETIDE SYNTHASE ACYL CARRIER PROTEIN FROM STREPTOMYCES COELICOLOR A3(2), NMR, 24 STRUCTURES

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-Y01:
CHOLESTEROL HEMISUCCINATE

ChemComp-HOH:
WATER

ChemComp-PG2:
PROSTAGLANDIN D2

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsMEMBRANE PROTEIN / GPCR / cryo-EM / DP1 / BW245C / prostaglandin D2 receptor / prostanoid DP receptor / PGD receptor / PTGDR / Gs protein / DP1-selective agonist / PGD2

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