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| Title | TGM6 is a helminth secretory product that mimics TGF-beta binding to TGFBR2 to antagonize signaling in fibroblasts. |
|---|---|
| Journal, issue, pages | Nat Commun, Vol. 16, Page 1847-1847, Year 2025 |
| Publish date | Nov 8, 2024 (structure data deposition date) |
Authors | White, S.E. / Schwartze, T.A. / Mukundan, A. / Schoenherr, C. / Singh, S.P. / van Dinther, M. / Cunningham, K.T. / White, M.P.J. / Campion, T. / Pritchard, J. ...White, S.E. / Schwartze, T.A. / Mukundan, A. / Schoenherr, C. / Singh, S.P. / van Dinther, M. / Cunningham, K.T. / White, M.P.J. / Campion, T. / Pritchard, J. / Hinck, C.S. / Ten Dijke, P. / Inman, G.J. / Maizels, R.M. / Hinck, A.P. |
External links | Nat Commun / PubMed:39984487 |
| Methods | X-ray diffraction |
| Resolution | 1.4 Å |
| Structure data | ![]() PDB-9e9g: |
| Chemicals | ![]() ChemComp-GOL: ![]() ChemComp-CL: ![]() ChemComp-NA: ![]() ChemComp-CAC: ![]() ChemComp-HOH: |
| Source |
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Keywords | IMMUNOSUPPRESSANT / Inhibitor / Complex / TGF-beta mimic / HpTGM / TGM6 / TGM6-D3 / TGF-beta / TbRII / fibroblasts |
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homo sapiens (human)
heligmosomoides polygyrus (invertebrata)
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