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Structure paper

TitleThe structural basis for de novo DNA methylation in chromatin
Journal, issue, pagesTo Be Published
Publish dateOct 22, 2024 (structure data deposition date)
AuthorsXie X / Liu M / Zhou XE / Worden E / Jones P
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.14 - 7.71 Å
Structure data

47448

9e2d

EMDB-47448, PDB-9e2d:
Cryo-EM structure of human DNMT3A2-DNMT3B3 complex bound to a di-nucleosome with a five base pair linker
Method: EM (single particle) / Resolution: 6.08 Å

47450

9e2f

EMDB-47450, PDB-9e2f:
Cryo-EM structure of a di-nucleosome with a five base pair linker
Method: EM (single particle) / Resolution: 5.9 Å

47461

9e2q

EMDB-47461, PDB-9e2q:
Cryo-EM structure of DNMT 3A2/3B3 tetramer in complex with a di-nucleosome with a six base pair linker
Method: EM (single particle) / Resolution: 3.14 Å

47462

9e2r

EMDB-47462, PDB-9e2r:
Cryo-EM structure of human DNMT3A2-DNMT3B3 complex bound to a di-nucleosome and an histone-3 peptide
Method: EM (single particle) / Resolution: 7.71 Å

47479

9e3d

EMDB-47479, PDB-9e3d:
Cryo-EM structure of DNMT 3A2/3B3 tetramer in complex with a di-nucleosome with K120R mutant H2B
Method: EM (single particle) / Resolution: 3.8 Å

47495

9e3r

EMDB-47495, PDB-9e3r:
Cryo-EM structure of PWWP domain deleted DNMT 3A2/3B3 in complex with a di-nucleosome
Method: EM (single particle) / Resolution: 6.9 Å

47496

9e3u

EMDB-47496, PDB-9e3u:
Cryo-EM structure of DNMT 3A2/3B3 tetramer bound to a di-nucleosome with a 25 base-pair linker
Method: EM (single particle) / Resolution: 4.9 Å

47499

9e49

EMDB-47499, PDB-9e49:
Cryo-EM structure of a di-nucleosome with an eight base-pair linker
Method: EM (single particle) / Resolution: 5.93 Å

EMDB-71301: Consensus map for Cryo-EM structure of DNMT3A2/3B3 tetramer in complex with a 167H3K36me2 nucleosome
Method: EM (single particle) / Resolution: 3.63 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN/DNA / DNMT3A / DNMT3B / nucleosome / DNA methylation / DNA BINDING PROTEIN / DNA BINDING PROTEIN-DNA complex / DNMT 3A2/3B3 / di-nucleosome / methylation

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