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TitleBLM G-quadruplex stabilizers synergize with PARP inhibitor to kill BRCA wild-type colon cancer cells
Journal, issue, pagesTo Be Published
Publish dateSep 24, 2024 (structure data deposition date)
AuthorsWang, Y.Y. / Bian, Y.T. / Chen, X.Y. / Li, J.Z. / Liu, Y.S. / Kong, L.Y. / Wang, K.B.
External linksSearch PubMed
MethodsNMR (solution)
Structure data

PDB-9dqe:
NMR Solution structure of the 2:1 Coptisine- BLM-G4 Complex
Method: SOLUTION NMR

PDB-9jo0:
Solution structure of free BLM promoter G-quadruplex
Method: SOLUTION NMR

PDB-9jo1:
NMR Solution structure of the 2:1 Berberine-BLM-G4 Complex
Method: SOLUTION NMR

Chemicals

ChemComp-KPT:
6,7-dihydro[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquino[3,2-a]isoquinolin-5-ium

ChemComp-BER:
BERBERINE / alkaloid*YM

Source
  • homo sapiens (human)
KeywordsDNA / BLM promoter / G-quadruplex / coptisine / complex / NMR solution structure / berberine

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