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Structure paper

TitleLactate dehydrogenase is the Achilles' heel of Lyme disease bacterium Borreliella burgdorferi.
Journal, issue, pagesMbio, Vol. 16, Page e0372824-e0372824, Year 2025
Publish dateSep 23, 2024 (structure data deposition date)
AuthorsSze, C.W. / Lynch, M.J. / Zhang, K. / Neau, D.B. / Ealick, S.E. / Crane, B.R. / Li, C.
External linksMbio / PubMed:40111021
MethodsX-ray diffraction
Resolution2.11 Å
Structure data

PDB-9dq7:
Borrelia burgdorferi LDH with NADH, oxamate and FBS
Method: X-RAY DIFFRACTION / Resolution: 2.11 Å

Chemicals

ChemComp-6V0:
[[(2~{R},3~{S},4~{R},5~{R})-5-(5-aminocarbonyl-2~{H}-pyridin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate

ChemComp-OXM:
OXAMIC ACID

ChemComp-CA:
Unknown entry

ChemComp-FBP:
1,6-di-O-phosphono-beta-D-fructofuranose

ChemComp-HOH:
WATER

Source
  • borreliella burgdorferi (Lyme disease spirochete)
KeywordsOXIDOREDUCTASE / lactate dehydrogenase / FBS / oxamate / NADH

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