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TitleHydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma.
Journal, issue, pagesSci Adv, Vol. 11, Page eadx7687-eadx7687, Year 2025
Publish dateSep 12, 2024 (structure data deposition date)
AuthorsShishikura, K. / Li, J. / Chen, Y. / McKnight, N.R. / Keeley, T.P. / Bustin, K.A. / Barr, E.W. / Chilkamari, S.R. / Ayub, M. / Kim, S.W. ...Shishikura, K. / Li, J. / Chen, Y. / McKnight, N.R. / Keeley, T.P. / Bustin, K.A. / Barr, E.W. / Chilkamari, S.R. / Ayub, M. / Kim, S.W. / Lin, Z. / Hu, R.M. / Hicks, K. / Wang, X. / O'Rourke, D.M. / Martin Bollinger Jr., J. / Binder, Z.A. / Parsons, W.H. / Martemyanov, K.A. / Liu, A. / Matthews, M.L.
External linksSci Adv / PubMed:41091880
MethodsX-ray diffraction
Resolution1.89 - 2.39 Å
Structure data

PDB-9dma:
Crystal structure of cobalt-bound human ADO C18S/C239S variant in complex with hydralazine at 1.89 Angstrom resolution
Method: X-RAY DIFFRACTION / Resolution: 1.89 Å

PDB-9dy4:
Crystal structure of iron-bound human ADO C18S/C239S variant soaked in hydralazine at 2.39 Angstrom resolution
Method: X-RAY DIFFRACTION / Resolution: 2.39 Å

Chemicals

ChemComp-CO:
Unknown entry

ChemComp-HLZ:
1-hydrazinophthalazine / medication*YM

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-FE2:
Unknown entry

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / cysteamine dioxygenase; cobalt-bound human ADO / cysteamine dioxygenase / cobalt-bound human ADO

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