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TitleDesigned miniproteins potently inhibit and protect against MERS-CoV. MERS-CoV S in complex with miniprotein cb3_GGGSGGGS_SB175, linker 7 (Local refinement of two RBDs and 2 miniproteins)
Journal, issue, pagesTo Be Published
Publish dateSep 9, 2024 (structure data deposition date)
AuthorsTortorici MA / Veesler D
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.3 Å
Structure data

46960

9dkk

EMDB-46960, PDB-9dkk:
Designed miniproteins potently inhibit and protect against MERS-CoV. MERS-CoV S in complex with miniprotein cb3_GGGSGGGS_SB175, linker 7 (Local refinement of two RBDs and 2 miniproteins)
Method: EM (single particle) / Resolution: 3.3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • middle east respiratory syndrome-related coronavirus
  • synthetic construct (others)
KeywordsVIRAL PROTEIN / Coronavirus / betacoronavirus / MERS-CoV / single particle cryo-EM / neutralization assays / binding assays / miniproteins inhibitors / fusion assays / in vivo protection / Structural Genomics / Seattle Structural Genomics Center for Infectious Disease / SSGCID

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