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TitleA global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein.
Journal, issue, pagesCell Rep, Vol. 44, Issue 4, Page 115499, Year 2025
Publish dateApr 2, 2025
AuthorsSharon L Schendel / Xiaoying Yu / Peter J Halfmann / Jarjapu Mahita / Brendan Ha / Kathryn M Hastie / Haoyang Li / Daniel Bedinger / Camille Troup / Kan Li / Natalia Kuzmina / Jordi B Torrelles / Jennifer E Munt / Melissa Mattocks / Mary Osei-Twum / Heather M Callaway / / Stephen Reece / Anne Palser / Paul Kellam / S Moses Dennison / Richard H C Huntwork / Gillian Q Horn / Milite Abraha / Elizabeth Feeney / Luis Martinez-Sobrido / Paula A Pino / Amberlee Hicks / Chengjin Ye / Jun-Gyu Park / Billie Maingot / Sivakumar Periasamy / Michael Mallory / Trevor Scobey / Marie-Noelle Lepage / Natalie St-Amant / Sarwat Khan / Anaïs Gambiez / / Ralph S Baric / Alexander Bukreyev / Luc Gagnon / Timothy Germann / Yoshihiro Kawaoka / Georgia D Tomaras / Bjoern Peters / Erica Ollmann Saphire /
PubMed AbstractThe Coronavirus Immunotherapeutic Consortium (CoVIC) conducted side-by-side comparisons of over 400 anti-SARS-CoV-2 spike therapeutic antibody candidates contributed by large and small companies as ...The Coronavirus Immunotherapeutic Consortium (CoVIC) conducted side-by-side comparisons of over 400 anti-SARS-CoV-2 spike therapeutic antibody candidates contributed by large and small companies as well as academic groups on multiple continents. Nine reference labs analyzed antibody features, including in vivo protection in a mouse model of infection, spike protein affinity, high-resolution epitope binning, ACE-2 binding blockage, structures, and neutralization of pseudovirus and authentic virus infection, to build a publicly accessible dataset in the database CoVIC-DB. High-throughput, high-resolution binning of CoVIC antibodies defines a broad and predictive landscape of antibody epitopes on the SARS-CoV-2 spike protein and identifies features associated with durable potency against multiple SARS-CoV-2 variants of concern and high in vivo efficacy. Results of the CoVIC studies provide a guide for selecting effective and durable antibody therapeutics and for immunogen design as well as providing a framework for rapid response to future viral disease outbreaks.
External linksCell Rep / PubMed:40184253 / PubMed Central
MethodsEM (single particle)
Resolution2.7 Å
Structure data

46892

9dhy

EMDB-46892, PDB-9dhy:
Structure of SARS-CoV-2 spike in complex with antibody Fab COVIC-154
Method: EM (single particle) / Resolution: 2.7 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / VIRAL PROTEIN / glycoprotein / immune system / antibody / SARS-CoV-2 / COVID / VIRAL PROTEIN-Immune System complex / coronavirus / ANTIVIRAL PROTEIN

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