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TitleCrystal structure and mutagenesis of a nucleic acid-binding BRCT domain in human PARP4.
Journal, issue, pagesJ. Biol. Chem., Vol. 301, Page 110277-110277, Year 2025
Publish dateAug 29, 2024 (structure data deposition date)
AuthorsFrigon, L. / Pascal, J.M.
External linksJ. Biol. Chem. / PubMed:40412520
MethodsX-ray diffraction
Resolution1.75 - 2.1 Å
Structure data

PDB-9dev:
PARP4 BRCT domain
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-9dfo:
PARP4 BRCT domain K31Q mutant
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-9dfp:
PARP4 BRCT domain K23/24Q mutant
Method: X-RAY DIFFRACTION / Resolution: 1.92 Å

PDB-9dfq:
PARP4 BRCT domain F39Q mutant
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-9dfr:
PARP4 BRCT domain F39A mutant
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PARP family / ADP-ribosyltransferase / marylation / vault

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