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TitleSHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy.
Journal, issue, pagesCancer Discov, Vol. 13, Page 1789-1801, Year 2023
Publish dateApr 30, 2024 (structure data deposition date)
AuthorsDrilon, A. / Sharma, M.R. / Johnson, M.L. / Yap, T.A. / Gadgeel, S. / Nepert, D. / Feng, G. / Reddy, M.B. / Harney, A.S. / Elsayed, M. ...Drilon, A. / Sharma, M.R. / Johnson, M.L. / Yap, T.A. / Gadgeel, S. / Nepert, D. / Feng, G. / Reddy, M.B. / Harney, A.S. / Elsayed, M. / Cook, A.W. / Wong, C.E. / Hinklin, R.J. / Jiang, Y. / Brown, E.N. / Neitzel, N.A. / Laird, E.R. / Wu, W.I. / Singh, A. / Wei, P. / Ching, K.A. / Gaudino, J.J. / Lee, P.A. / Hartley, D.P. / Rothenberg, S.M.
External linksCancer Discov / PubMed:37269335
MethodsX-ray diffraction
Resolution2.06 Å
Structure data

PDB-9blg:
Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with PF-07284892
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

Chemicals

PDB-1aq1:
HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/INHIBITOR / PHOSPHATASE / INHIBITOR / SHP2 / HYDROLASE / HYDROLASE-INHIBITOR complex

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