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| Title | PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network. |
|---|---|
| Journal, issue, pages | Structure, Vol. 32, Page 2352-2363.e8, Year 2024 |
| Publish date | Apr 16, 2024 (structure data deposition date) |
Authors | Huber, A.D. / Lin, W. / Poudel, S. / Miller, D.J. / Chen, T. |
External links | Structure / PubMed:39389062 |
| Methods | X-ray diffraction |
| Resolution | 2.6 Å |
| Structure data | ![]() PDB-9beq: |
| Chemicals | ![]() ChemComp-AP1: ![]() ChemComp-HOH: |
| Source |
|
Keywords | TRANSCRIPTION / PXR / pregnane X receptor / NR1I2 / nuclear receptor / drug metabolism / AP1867 / FKBP |
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