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Structure paper

TitleStructural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 121, Page e2407066121-e2407066121, Year 2024
Publish dateApr 7, 2024 (structure data deposition date)
AuthorsSewa, A.S. / Besser, H.A. / Mathews, I.I. / Khosla, C.
External linksProc. Natl. Acad. Sci. USA / PubMed:38959038
MethodsX-ray diffraction
Resolution1.84 - 2.75 Å
Structure data

PDB-9bc2:
Transglutaminase 2 - Open State
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-9bc3:
Transglutaminase 2 - Alternate state
Method: X-RAY DIFFRACTION / Resolution: 2.52 Å

PDB-9bc4:
Transglutaminase 2 - Intermediate State
Method: X-RAY DIFFRACTION / Resolution: 1.84 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSFERASE / Transglutaminase 2 / Open state / Alternate state / Intermediate state

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