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-Structure paper
Title | Design and synthesis of novel and potent allosteric HIV-1 integrase inhibitors with a spirocyclic moiety. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 110, Page 129864-129864, Year 2024 |
Publish date | May 10, 2024 (structure data deposition date) |
Authors | Adachi, K. / Manabe, T. / Yamasaki, T. / Suma, A. / Orita, T. / Furuzono, T. / Adachi, T. / Ohata, Y. / Akiyama, Y. / Miyazaki, S. |
External links | Bioorg. Med. Chem. Lett. / PubMed:38942126 |
Methods | X-ray diffraction |
Resolution | 1.82 - 1.95 Å |
Structure data | PDB-8zh4: PDB-8zha: |
Chemicals | ChemComp-PG4: PDB-1l1v: ChemComp-SO4: ChemComp-HOH: PDB-1l1w: |
Source |
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Keywords | VIRAL PROTEIN / HIV / integrase / inhibitor |