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TitleStructural insights into the human MRP4 mediating multiple drug resistance (MDR) to vincristine and 5-FU and reversal of MDR by lapatinib
Journal, issue, pagesTo Be Published
Publish dateApr 27, 2024 (structure data deposition date)
AuthorsXie Z / Long F
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.92 Å
Structure data

39908

8zbr

EMDB-39908, PDB-8zbr:
Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (apo-form)
Method: EM (single particle) / Resolution: 2.92 Å

Chemicals

ChemComp-CLR:
CHOLESTEROL

ChemComp-Y01:
CHOLESTEROL HEMISUCCINATE

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / ATP-binding cassette sub-family C member 4 / Multidrug resistance proteins (MRPs) / multidrug-resistance (MDR) / TRANSPORT PROTEIN

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