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TitleThe WDR11 complex is a receptor for acidic-cluster-containing cargo proteins.
Journal, issue, pagesCell, Vol. 187, Issue 16, Page 4272-4288.e20, Year 2024
Publish dateAug 8, 2024
AuthorsHuaqing Deng / Guowen Jia / Ping Li / Yingying Tang / Lin Zhao / Qin Yang / Jia Zhao / Jinrui Wang / Yingfeng Tu / Xin Yong / Sitao Zhang / Xianming Mo / Daniel D Billadeau / Zhaoming Su / Da Jia /
PubMed AbstractVesicle trafficking is a fundamental process that allows for the sorting and transport of specific proteins (i.e., "cargoes") to different compartments of eukaryotic cells. Cargo recognition ...Vesicle trafficking is a fundamental process that allows for the sorting and transport of specific proteins (i.e., "cargoes") to different compartments of eukaryotic cells. Cargo recognition primarily occurs through coats and the associated proteins at the donor membrane. However, it remains unclear whether cargoes can also be selected at other stages of vesicle trafficking to further enhance the fidelity of the process. The WDR11-FAM91A1 complex functions downstream of the clathrin-associated AP-1 complex to facilitate protein transport from endosomes to the TGN. Here, we report the cryo-EM structure of human WDR11-FAM91A1 complex. WDR11 directly and specifically recognizes a subset of acidic clusters, which we term super acidic clusters (SACs). WDR11 complex assembly and its binding to SAC-containing proteins are indispensable for the trafficking of SAC-containing proteins and proper neuronal development in zebrafish. Our studies thus uncover that cargo proteins could be recognized in a sequence-specific manner downstream of a protein coat.
External linksCell / PubMed:39013469 / PubMed Central
MethodsEM (single particle)
Resolution3.3 - 7.4 Å
Structure data

38300
EMDB entry, No image

8xfb

EMDB-38300, PDB-8xfb:
Cryo-EM structure of partial dimeric WDR11-FAM91A1 complex
Method: EM (single particle) / Resolution: 3.4 Å

39863
EMDB entry, No image

8z9m

EMDB-39863, PDB-8z9m:
Cryo-EM structure of dimeric WDR11-FAM91A1 complex
Method: EM (single particle) / Resolution: 3.3 Å


EMDB entry, No image

EMDB-39943: Cryo-EM structure of dimeric WDR11-FAM91A1 complex Body2
Method: EM (single particle) / Resolution: 3.3 Å


EMDB entry, No image

EMDB-39947: Cryo-EM structure of dimeric WDR11-FAM91A1 complex Body1
Method: EM (single particle) / Resolution: 3.3 Å


EMDB entry, No image

EMDB-39949: Cryo-EM structure of WDR11-dm-FAM91A1 complex
Method: EM (single particle) / Resolution: 7.4 Å

Source
  • homo sapiens (human)
KeywordsPROTEIN TRANSPORT / Cryo-EM / Vesicle Trafficking / Neural Development

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