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TitleA human monoclonal antibody targeting the monomeric N6 neuraminidase confers protection against avian H5N6 influenza virus infection.
Journal, issue, pagesNat Commun, Vol. 15, Issue 1, Page 8871, Year 2024
Publish dateOct 15, 2024
AuthorsMin Wang / Yuan Gao / Chenguang Shen / Wei Yang / Qi Peng / Jinlong Cheng / Han-Ming Shen / Yang Yang / George Fu Gao / Yi Shi /
PubMed AbstractThe influenza neuraminidase (NA) is a potential target for the development of a next-generation influenza vaccine, but its antigenicity is not well understood. Here, we isolate an anti-N6 human ...The influenza neuraminidase (NA) is a potential target for the development of a next-generation influenza vaccine, but its antigenicity is not well understood. Here, we isolate an anti-N6 human monoclonal antibody, named 18_14D, from an H5N6 avian influenza virus (AIV) infected patient. The antibody weakly inhibits enzymatic activity but confers protection in female mice, mainly via ADCC function. The cryo-EM structure shows that 18_14D binds to a unique epitope on the lateral surface of the N6 tetramer, preventing the formation of tightly closed NA tetramers. These findings contribute to the molecular understanding of protective immune responses to NA of AIVs in humans and open an avenue for the rational design of NA-based vaccines.
External linksNat Commun / PubMed:39402031 / PubMed Central
MethodsEM (single particle)
Resolution3.0 Å
Structure data

39762

8z4e

EMDB-39762, PDB-8z4e:
Structure of human 18_14D scFv and 1G01 scFv in complex with influenza virus neuraminidase from A/Yunan/DQ001/2016 (H5N6)
Method: EM (single particle) / Resolution: 3.0 Å

Chemicals

ChemComp-CA:
Unknown entry

Source
  • Influenza A virus (A/Yunan/DQ001/2016 (H5N6))
  • influenza a virus
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / influenza virus / neuraminidase / human monoclonal antibody / immunogen

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