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| Title | Repurposing Tolfenamic Acid to Anchor the Uncharacterized Pocket of the PUB Domain for Proteolysis of the Atypical E3 Ligase HOIP. |
|---|---|
| Journal, issue, pages | Acs Chem. Biol., Vol. 19, Page 2469-2476, Year 2024 |
| Publish date | Apr 14, 2024 (structure data deposition date) |
Authors | Zhong, F. / Zhou, Y. / Liu, M. / Wang, L. / Li, F. / Zhang, J. / Han, Z. / Shi, Y. / Gao, J. / Ruan, K. |
External links | Acs Chem. Biol. / PubMed:39513479 |
| Methods | X-ray diffraction |
| Resolution | 2.3 - 2.63 Å |
| Structure data | ![]() PDB-8z30: ![]() PDB-8z36: |
| Chemicals | ![]() ChemComp-PEG: ![]() ChemComp-TLF: ![]() ChemComp-PE4: ![]() ChemComp-TOE: ![]() ChemComp-HOH: ![]() ChemComp-SRE: |
| Source |
|
Keywords | LIGASE / E3 ubiquitin-protein ligase HOIP / sertraline |
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