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TitleDiscovery and Hit to Lead Optimization of Macrocyclic Peptides as Novel Tropomyosin Receptor Kinase A Antagonists.
Journal, issue, pagesJ. Med. Chem., Vol. 67, Page 11197-11208, Year 2024
Publish dateMar 25, 2024 (structure data deposition date)
AuthorsYamada, T. / Mihara, K. / Ueda, T. / Yamauchi, D. / Shimizu, M. / Ando, A. / Mayumi, K. / Nakata, Z. / Mikamiyama, H.
External linksJ. Med. Chem. / PubMed:38950284
MethodsX-ray diffraction
Resolution2.26 - 2.34 Å
Structure data

PDB-8ytd:
Crystal Structure of TrkA D5 domain in complex with two different macrocyclic peptides
Method: X-RAY DIFFRACTION / Resolution: 2.34 Å

PDB-8yte:
Crystal Structure of TrkA D5 domain in complex with macrocyclic peptide
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-GM1:
AMINOMETHYLAMIDE

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSFERASE / cyclic peptide

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