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TitleSelective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders.
Journal, issue, pagesCell, Vol. 187, Page 7126-7142.e20, Year 2024
Publish dateJan 31, 2024 (structure data deposition date)
AuthorsLu, P. / Cheng, Y. / Xue, L. / Ren, X. / Xu, X. / Chen, C. / Cao, L. / Li, J. / Wu, Q. / Sun, S. ...Lu, P. / Cheng, Y. / Xue, L. / Ren, X. / Xu, X. / Chen, C. / Cao, L. / Li, J. / Wu, Q. / Sun, S. / Hou, J. / Jia, W. / Wang, W. / Ma, Y. / Jiang, Z. / Li, C. / Qi, X. / Huang, N. / Han, T.
External linksCell / PubMed:39488207
MethodsX-ray diffraction
Resolution1.6 - 1.89 Å
Structure data

PDB-8y58:
Crystal structure of TRIM21 PRYSPRY (D355A) in complex with acepromazine.
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-8y59:
Crystal structure of TRIM21 PRYSPRY (D355A) in complex with (S)-hydroxyl-acepromazine.
Method: X-RAY DIFFRACTION / Resolution: 1.89 Å

PDB-8y5b:
Crystal structure of TRIM21 PRYSPRY (D355A) in complex with (R)-hydroxyl-acepromazine.
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

Chemicals

ChemComp-PMZ:
1-[10-(3-DIMETHYLAMINO-PROPYL)-10H-PHENOTHIAZIN-2-YL]-ETHANONE / antipsychotic*YM

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

PDB-1d5y:
CRYSTAL STRUCTURE OF THE E. COLI ROB TRANSCRIPTION FACTOR IN COMPLEX WITH DNA

PDB-1d5z:
X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDOMIMETIC AND SEB

Source
  • homo sapiens (human)
KeywordsLIGASE / TRIM21 / PRYSPRY / acepromazine / (S)-hydroxyl-acepromazine / (R)-hydroxyl-acepromazine

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