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TitleDeubiquitinase inhibitors: Targeting SARS-CoV-2 papain-like protease with antiviral efficacy in a murine model.
Journal, issue, pagesFebs J., Year 2026
Publish dateNov 9, 2023 (structure data deposition date)
AuthorsChoudhary, S. / Nehul, S. / Nagaraj, S.K. / Narayan, R. / Verma, S. / Sharma, S. / Kumari, A. / Rani, R. / Saha, A. / Sircar, D. ...Choudhary, S. / Nehul, S. / Nagaraj, S.K. / Narayan, R. / Verma, S. / Sharma, S. / Kumari, A. / Rani, R. / Saha, A. / Sircar, D. / Kaliappan, A. / Tripathi, S. / Sharma, G.K. / Kumar, P. / Tomar, S.
External linksFebs J. / PubMed:41527419
MethodsX-ray diffraction
Resolution2.3 - 2.7 Å
Structure data

PDB-8x1x:
SARS-CoV-2 Papain like protease (PLpro) in complex with inhibitor Lithocholic acid
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-8xtd:
SARS-CoV-2 papain-like-protease (PLpro) in complex with inhibitor Linagliptin
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-4OA:
(3beta,5beta,14beta,17alpha)-3-hydroxycholan-24-oic acid / detergent*YM

ChemComp-GOL:
GLYCEROL

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-356:
8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-d / medication, inhibitor*YM

Source
  • severe acute respiratory syndrome coronavirus 2
KeywordsHYDROLASE / Papain like protease (PLpro) / SARS-CoV-2 / Lithocholic acid / COVID-19 / VIRAL PROTEIN / PLpro / Linagliptin / Nsp3 / Complex

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