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-Structure paper
Title | Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 7197-7223, Year 2024 |
Publish date | Nov 22, 2023 (structure data deposition date) |
Authors | Wang, J. / Rong, Q. / Ye, L. / Fang, B. / Zhao, Y. / Sun, Y. / Zhou, H. / Wang, D. / He, J. / Cui, Z. ...Wang, J. / Rong, Q. / Ye, L. / Fang, B. / Zhao, Y. / Sun, Y. / Zhou, H. / Wang, D. / He, J. / Cui, Z. / Zhang, Q. / Kang, D. / Hu, L. |
External links | J. Med. Chem. / PubMed:38655686 |
Methods | X-ray diffraction |
Resolution | 1.58 - 1.61 Å |
Structure data | PDB-8x71: PDB-8x73: |
Chemicals |
ChemComp-YCC: ChemComp-HOH:
ChemComp-YC0: |
Source |
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Keywords | OXIDOREDUCTASE/INHIBITOR / OXIDOREDUCTASE-INHIBITOR COMPLEX |