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-Structure paper
Title | Deviated binding of anti-HBV nucleoside analog E-CFCP-TP to the reverse transcriptase active site attenuates the effect of drug-resistant mutations. |
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Journal, issue, pages | Sci Rep, Vol. 14, Page 15742-15742, Year 2024 |
Publish date | Nov 9, 2023 (structure data deposition date) |
Authors | Yasutake, Y. / Hattori, S.I. / Kumamoto, H. / Tamura, N. / Maeda, K. / Mitsuya, H. |
External links | Sci Rep / PubMed:38977798 |
Methods | X-ray diffraction |
Resolution | 2.31 - 2.7 Å |
Structure data | PDB-8x1z: PDB-8x20: PDB-8x21: PDB-8x22: |
Chemicals | ChemComp-GOL: ChemComp-MG:
ChemComp-XTE: ChemComp-HOH: ChemComp-ET9: ChemComp-DGT: |
Source |
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Keywords | TRANSFERASE / reverse transcriptase / HIV-1 / HBV / drug resistance / nucleoside analogue / E-CFCP / entecavir |