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TitleSynthesis, activity, and their relationships of 2,4-diaminonicotinamide derivatives as EGFR inhibitors targeting C797S mutation.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 98, Page 129575-129575, Year 2023
Publish dateSep 14, 2023 (structure data deposition date)
AuthorsKageji, H. / Momose, T. / Nagamoto, Y. / Togashi, N. / Yasumatsu, I. / Nishikawa, Y. / Kihara, K. / Hiramoto, K. / Minami, M. / Kasanuki, N. ...Kageji, H. / Momose, T. / Nagamoto, Y. / Togashi, N. / Yasumatsu, I. / Nishikawa, Y. / Kihara, K. / Hiramoto, K. / Minami, M. / Kasanuki, N. / Isoyama, T. / Naito, H.
External linksBioorg. Med. Chem. Lett. / PubMed:38065292
MethodsX-ray diffraction
Resolution2.55 Å
Structure data

PDB-8wd4:
EGFR(L858R/T790/C797S) in complex with compound 5j
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

Chemicals

ChemComp-W7W:
~{N}-[3,3-bis(fluoranyl)propyl]-4-[[(2~{S})-butan-2-yl]amino]-6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]pyridine-3-carboxamide

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / EGFR / C797S / Drug Discovery

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