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TitleUncommon Arrangement of Self-resistance Allows Biosynthesis of de novo Purine Biosynthesis Inhibitor that Acts as an Immunosuppressor.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 145, Page 26883-26889, Year 2023
Publish dateAug 30, 2023 (structure data deposition date)
AuthorsSato, M. / Sakano, S. / Nakahara, M. / Tamura, Y. / Hara, K. / Hashimoto, H. / Tang, Y. / Watanabe, K.
External linksJ. Am. Chem. Soc. / PubMed:38051581
MethodsX-ray diffraction
Resolution2.81 Å
Structure data

PDB-8w7d:
Crystal structure of EcPPAT-FR901483 complex
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

Chemicals

ChemComp-7TG:
[(1S,3S,6S,7S,8R,9S)-6-[(4-methoxyphenyl)methyl]-3-(methylamino)-7-oxidanyl-5-azatricyclo[6.3.1.0^1,5]dodecan-9-yl] dihydrogen phosphate

Source
  • escherichia coli k-12 (bacteria)
KeywordsTRANSFERASE / PPAT / FR901483 / immunosuppressant / self-resistance enzyme / molecular targeted drug

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